The FitzSimmons ship is most likely the most popular ship in the Agents of S.H.I.E.L.D. fandom with SkyeWard as the second. Since the start of Season 1, many fans have followed this ship and have wanted them to get together.
In the events of Season 3, many fans were distraught of the introduction of JemmaWill, with many expressing their outrage in the tumblr tags. However, many fans were overjoyed when they later kissed for the first time.